Where to buy Sulfasalazine
You can easily and quite conveniently buy sulfasalazine online. Online pharmacies operate twenty four seven making it possible to place your order any time, having your drug delivered conveniently to your doorstep without any need to see a doctor and get a prescription. Affordable Sulfasalazine 500mg without prescription is in no way worse in quality than the brand name medicine with the same active ingredient. So, buying Generic Azulfidine without prescription seems like a great way to get the required treatment without overpaying for it or going anywhere.
What is it prescribed for?
Sulfasalazine is an oral anti-inflammatory medication that reduces inflammation and swelling. It is usually prescribed for the treatment of diarrhea, bowel inflammation and rectal bleeding. It can also be recommended for treating abdominal pain in patients with a condition known as ulcerative colitis. Sulfasalazine is also a second-choice drug for the treatment of rheumatoid arthritis that did not respond to the first-choice treatment.
You need to consult a qualified medical professional before starting to take this medicine. Sulfasalazine is usually taken four times a day at evenly spaced intervals so that there would be 8 hours between every two doses. You should try to avoid missing any doses, as this will affect the efficiency of your treatment. It’s best to take Sulfasalazine after having a meal or a snack of some kind, drinking a full glass of water right after. That way, you can avoid stomach upset that’s quite common. Make sure you get plenty of fluids during the course of the treatment. Keep taking Sulfasalazine even if your condition improves, until you are supposed to stop per your doctor’s directions.
Information about Sulfasalazine
From the nervous system and sensory organs:
- sleep disturbances
- peripheral neuropathy
From the side of cardiovascular system and blood:
- hemolytic anemia
On the part of the digestive tract:
- abdominal pain
- blood in feces
On the part of the urogenital system:
- renal dysfunction
- interstitial nephritis
- transient oligospermia and infertility
- skin rash
- Lyell’s syndrome
- Stevens-Johnson syndrome
- anaphylactic shock
Mechanism of action
In connective tissue, the intestinal wall dissociates into 5-aminosalicylic acid, which causes the anti-inflammatory properties of sulfasalazine, and sulfapyridine, a competitive para-aminobenzoic acid antagonist, which stops folate synthesis in microbial cells and causes antibacterial activity. Affects diplococci, streptococci, gonococci, Escherichia coli.
Poorly absorbed from the digestive tract (no more than 10%). Subjected to intestinal microflora splitting to form 60–80% sulfapyridine and 25% 5-aminosalicylic acid (5-ASA). Plasma protein binding of sulfasalazine – 99%, sulfapyridine – 50%, 5-ASA – 43%. Sulfapyridine undergoes biotransformation in the liver by hydroxylation to form inactive metabolites, 5-ASA is acetylated. T1 / 2: sulfasalazine – 5–10 hours, sulfapyridine – 6–14 hours, 5-ASA – 0.6–1.4 hours. With feces 5% sulfapyridine and 67% 5-ASA are eliminated, and kidneys – 75–91% sulfasalazine (within 3 days).
Use during pregnancy and lactation
In pregnancy, it is possible only under strict indications and in the minimum effective dose.
Category of action on the fetus by the FDA – B.
At the time of treatment should stop breastfeeding.
Caution is prescribed to patients with impaired renal or liver function, bronchial asthma, and allergic reactions. During the period of treatment it is necessary to systematically monitor the blood picture and the level of liver enzymes.
Possible staining in orange-yellow skin, urine, soft contact lenses.